Infertility affects 50 to 80 million (between 8 and 12% of couples). Male factor is a cause of infertility in almost half of the cases, mainly due to oligoasthenoteratozoospermia. DNA fragmentation is now considered an important factor in the aetiology of male infertility. We studied the effects on semen analysis and on DNA fragmentation of in vivo admnistration of Myo-Inositol and Tribulus Terrestris plus Alga Ecklonia plus Biovis (Tradafertil; Tradapharma Sagl, Swizerland) in men with previously diagnosed male infertility.
Sixty patients were enrolled in the present study and were randomized into two subgroups: the group A who received Myo-inositol 1000 mg, Tribulus Terrestris 300 mg, Alga Ecklonia Bicyclis 200 mg and Biovis one tablet a day for 90 days, and the group B (placebo group) who received one placebo tablet a day for 90 days. The primary efficacy outcome was the improvement of semen characteristics after 3 months’ therapy and the secondary outcome was the reduction of the DNA fragmentation after treatment.
The groups were homogenous for age, hormonal levels, sperm concentration and all parameters of sperm analysis. Sperm concentration and progressive motility improved after treatment with Tradafertil (3.82 Mil/ml vs. 1.71 Mil/ml; p<0.05; 4.86% vs. 1.00%; p<0.05) as well as the DNA fragmentation (-1.64% vs -0.39%, p<0.001). No side effects were revealed.
In conclusion, we can affirm that Tradafertil is safe and tolerable. It is a new phytotherapic approach to Oligoasthenoteratospermia (OAT) syndrome that could lead to good results without interacting with
Urologia 2017; 84(2): 79 - 82
Article Type: ORIGINAL RESEARCH ARTICLE
AuthorsMarco Capece, Giuseppe Romeo, Antonio Ruffo, Leo Romis, Salvatore Mordente, Giovanni Di Lauro
- • Accepted on 30/11/2016
- • Available online on 28/12/2016
- • Published in print on 28/04/2017
This article is available as full text PDF.
- Capece, Marco [PubMed] [Google Scholar] 1, * Corresponding Author (firstname.lastname@example.org)
- Romeo, Giuseppe [PubMed] [Google Scholar] 1
- Ruffo, Antonio [PubMed] [Google Scholar] 1
- Romis, Leo [PubMed] [Google Scholar] 2
- Mordente, Salvatore [PubMed] [Google Scholar] 2
- Di Lauro, Giovanni [PubMed] [Google Scholar] 2
Department of Urology, University Federico II of Naples, Naples - Italy
Department of Urology, Hospital Santa Maria delle Grazie of Pozzuoli, Pozzuoli (Naples) - Italy