Systemic chemotherapy in muscle invasive and metastatic bladder cancer: present and future


Bladder cancer is the most frequent among the urothelial tumors, and it is responsible for about 2% of all cancer mortality worldwide. The mainstay of chemotherapy treatment, both for muscle-invasive and metastatic disease, is cisplatin-based regimens. In recent years, ground-breaking results have been achieved with immunotherapy, which have led to important breakthroughs in the bladder cancer treatment scenario, with the approval of several new agents. New insights derive from a greater characterization of the tumor genome, which could lead to developing new therapies, more personalized, in the near future.

Urologia 2017; 84(3): 130 - 141

Article Type: REVIEW



Gabriella Del Bene, Cora N. Sternberg

Article History


Financial support: Cora N. Sternberg had received honoraria or research funding from BMS, Astra Zeneca, Novartis, Merck, Pfizer, Onco-Genyx.
Conflicts of interest: Gabriella Del Bene declared no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors.

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  •  Department of Medical Oncology, San Camillo Forlanini Hospital, Padiglione Flajani, Rome - Italy
  •  Department of Experimental Medicine, “La Sapienza” University, Rome - Italy

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