Prostatic abscess in a patient with chronic granulomatous disease: a multi-disciplinary intervention



Chronic granulomatous disease (CGD) is a rare pathology that increases patients’ susceptibility to infections, given the inability to generate oxygen radicals to fight microorganisms.

In the context of CGD, primary prostatic involvement has been described only once in the past, in a pediatric patient.

Case report

We report the case of a 35-year old patient with CGD presenting with persistent fever. After hospital admission, blood and urine were sent for culture and antibiotic therapy was initiated. Patient´s conditions continued to deteriorate and an aggressive antibiotic therapy was administered to treat the septic scenario. Urine culture grew a multidrug-resistant Escherichia Coli. After patient’s condition improved, a CT scan was performed. The depiction showed multiple abscesses within the prostate. A rectal approach was excluded given patient’s underlying disease. A TURP was performed and prostatic pathology resolved. Patient was discharged on postoperative day 14. At 6-month follow-up he hasn’t experienced major infections.

To the best of our knowledge, this is the first case of septic shock originating from a prostatic abscess in an adult patient with CGD.


Aggressive medical therapy along with TURP resulted curative in our case. A multi-disciplinary approach was mandatory.

In press - Corrected proof

Article Type: CASE REPORT



Alberto Martini, Ioannis Katafigiotis, Sofia Kalantzi, Ioannis Anastasiou, Ioannis Adamakis, Aggelos Toskas, Constantinos A. Constantinides

Article History


Financial support: None.
Conflict of interest: None.

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  • Department of Urology, University of Florence, Careggi Hospital, Florence - Italy
  • First University Urology Clinic, Laiko Hospital, Athens - Greece
  • First Department of Propaedeutic Medicine, Laiko Hospital, Athens - Greece

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