Incidental prostatic stromal tumor of uncertain malignant potential (STUMP): histopathological and immunohistochemical findings
Urologia 2012; 79(1): 65 - 68
Article Type: CASE REPORT
DOI:10.5301/RU.2012.9099
Authors
Ettore De Berardinis, Gian Maria Busetto, Gabriele Antonini, Riccardo Giovannone, Mariarosaria Di Placido, Fabio M. Magliocca, Alessandro Di Silverio, Vincenzo Gentile
Abstract
Stromal prostate tumors are rare neoplastic proliferative lesions that have been classified into prostatic stromal tumor of uncertain malignant potential (STUMP) and prostatic stromal sarcoma (SS) based on these criteria: stromal cellularity, presence of mitotic figures, necrosis, and stromal overgrowth. A prostatic stromal tumor of uncertain malignant potential (STUMP) is a non-epithelial, mesenchymal spindle-cell tumor that can be classified as a specialized stromal tumor of the prostate. STUMPs have the capability to diffusely infiltrate the prostate gland and extend into adjacent tissues. Furthermore, they often recur and this is why they are considered as neoplastic entities. STUMPs usually tend to be not aggressive, but occasional cases have been reported with an extension into adjacent tissues. A few cases develop a sarcomatous dedifferentiation. A 67-year-old male referred to the Department of Urology, Sapienza Rome University, with acute urinary retention (AUR) and bladder overdistention. Digital rectal examination (DRE) showed the presence of a severe prostatic hyperplasia and a transvesical prostatic adenomectomy (TVPA) was performed. The pathological evaluation performed at the Department of Pathology, Sapienza Rome University, revealed an incidental diagnosis of prostatic STUMP. The patient’s follow-up is made every year with transrectal ultrasonography and nuclear magnetic resonance with spectroscopy, and every two years with a transperineal prostate biopsy to exclude a progression to a stromal sarcoma. After 5 years of follow-up the STUMP is still detectable but there is no sign of sarcoma. As a result of its relative rarity and lack of long-term follow-up, the prognosis of STUMP is unclear. Therapy varies from a wait-and-see approach to a radical retropubic prostatectomy.
Article History
- • Available online on 02/03/2012
- • Published in print on 22/03/2012
- • Accepted on 12/07/2012
This article is available as full text PDF.
Authors
- De Berardinis, Ettore
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Busetto, Gian Maria
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Antonini, Gabriele
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Giovannone, Riccardo
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Di Placido, Mariarosaria
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Magliocca, Fabio M.
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
- Di Silverio, Alessandro
[PubMed]
[Google Scholar]
Department of Urology, Santa Maria della Scaletta Hospital, Imola (Bo) – Italy
- Gentile, Vincenzo
[PubMed]
[Google Scholar]
Department of Urology, Sapienza Rome University, Rome – Italy
Article usage statistics
The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.