Advertisement

Effectiveness of highly purified urofollitropin treatment in patients with idiopathic azoospermia before testicular sperm extraction

Abstract

Introduction

Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins.

Methods

Fifty infertile men affected by idiopathic azoospermia were enrolled in this study, after undergoing medical history, physical and clinical examination, baseline semen parameters and hormonal plasma concentrations. Inclusion criteria were infertility for at least 2 years, idiopathic azoospermia, FSH <12 mIU/ml. Twenty-five patients were allocated to treatment with hFSH three times/week per 3 months (Fostimon), and 25 patients underwent just testicular sperm extraction (TESE) without medical treatment. All patients underwent, after 3 months, assisted reproduction techniques (ARTs) with TESE. The primary outcome was represented by the differences in the sperm retrieval rate (SRR) between groups, while the secondary outcomes were the differences in PR and fertilization rate (FR).

Results

We observed a PR of 15% (3/25) and 28% (7/25) in control and treated group, respectively. SRR after medical treatment and ART was 24% (6/25), while in the control group was 12.5% (2/25). The sperm in the ejaculate of five patients (20%) after medical treatment exhibited a mean concentration of 0.9 million/ml and a mean motility of 12%. The FR was significantly greater in the treatment group with respect to the control group, 30% and 20%, respectively.

Conclusions

FSH treatment showed greater efficacy rather than control by increasing the rate of PR and FR in azoospermic patients who underwent TESE.

In press - Corrected proof

Article Type: ORIGINAL RESEARCH ARTICLE

Article Subject: Andrology

DOI:10.5301/uj.5000253

Authors

Andrea Cocci, Gianmartin Cito, Giorgio I. Russo, Marco Falcone, Marco Capece, Massimiliano Timpano, Pier Andrea Della Camera, Simone Morselli, Giovanni Tasso, Girolamo Morelli, Giuseppe Morgia, Andrea Minervini, Sergio Serni, Marco Carini, Alessandro Natali, Mauro Gacci

Article History

Disclosures

Financial support: The authors have not received any funding for this study.
Conflict of interest: All authors declare that there is no conflict of interest regarding the publication of this paper.

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

Affiliations

  • Department of Urology, AOU Careggi, University of Florence, Florence - Italy
  • Department of Urology, University of Catania, Catania - Italy
  • Department of Urology, University of Turin, Turin - Italy
  • Department of Urology, University of Naples “Federico” II, Naples - Italy
  • Department of Urology, University of Pisa, Pisa - Italy

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.